Role of Cytochrome P450 monooxygenase (P450s) for insecticide resistance in Laodelphax striatellus (Fallén) (Hemiptera: Delphacidae): A review

Abstract : The small brown planthopper, Laodelphax striatellus (Fallén) (Hemiptera: Delphacidae) is a notorious phytophagous pest of rice and a vector of several plant diseases. The pest is difficult to chemically control because of its resistance to the most of insecticides. Insecticide resistance has long been associated with its oxidative detoxification by over-expression of cytochrome P450 monooxygenases (P450s) in insects, including L. striatellus. This article reviews the cytochrome P450s of L. striatellus that are usually over-expressed in its resistant strains and involved in insecticide resistance. In this review, the features of L. striatellus P450s are studied in order to investigate their catalytic role in insecticide resistance. The overexpressed P450 genes in resistant L. striatellus belongs to CYP3 family (CYP353D1v2, CYP314A1v2 and CYP306A2v2), CYP4 family (CYP4C71v2, CYP4C72, CYP439A1v3 and CYP4DE1) and CYP6 family (CYP6AY3v2, CYP6FU1, CYP6CW3v2 and CYP6CW1). The catalytic activities of these P450s were found to enhance from 1.39 to 7.64-fold in different insecticide selected (resistant) strain of L. striatellus including imidacloprid, deltamethrin, chlorpyrifos, and buprofezin. The catalytic role of specific P450s like CYP353D1v2, CYP4C71v2, CYP6AY3v2 and CYP353D1v2, CYP4C71v2, CYP6AY3v2 were investigated to metabolize imidacloprid and deltamethrin, respectively, whereas CYP353D1v2 was investigated for buprofezin metabolism. Besides, CYP353D1v2 and CYP6AY3v2 were associated with the cross-resistance among chlorpyrifos, deltamethrin, and imidacloprid. Moreover, a resistance irrelevant P450s named CYP417A2v2 was reported to catalyze imidacloprid in L. striatellus. By this study, a detailed understanding of various P450s of L. striatellus, and the catalytic role of specific P450s in insecticide resistance development is critically reviewed, which is quintessential for effective resistance management strategies as well as future research direction.
Keyword : Cytochrome P450 monooxygenases (P450s), over-expression, insecticide detoxification, resistance development, resistance management
Author(s) : Miah, M. A., Husna, A.
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Published Issue : 2024 Vol. 19 Number 1

2024 Vol. 19 Number 1